Water quality -- Calibration and evaluation of analytical methods and estimation of performance characteristics -- Part 2: Calibration strategy for non-linear second-order calibration functions

Document Number: NL ISO 8466 2 : 2009
Sector: Food Technology
TC: No
ICS: 13.060.50
It is not always possible to accurately describe the relationship between a set of calibration points with a rectilinear curve, even by decreasing the working range. Instead of the linear regression analysis, a least-squares fit to a second-order polynomial is applied (see test for linearity in 4.1.3 of ISO 8466-1:1990[1]). Using this fit, it is possible to calculate not only the calibration function but also the confidence interval associated with it. This part of ISO 8466 is intended primarily for use in method development and may not necessarily be applicable to all routine analyses.